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At the end of 2012 RIVM had 1621 employees (1457.22 FTE). About half were male.

The average age is 46. Most employees are between 35 and 54, but women are younger on average. The largest group of female employees is between 35 and 44, while nearly 20% are younger than 35. Most male employees are between 45 and 54. Two-thirds of RIVM employees aged 55+ are men.